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Methylation Protect is a comprehensive formula designed to support optimal methylation and help maintain healthy homocysteine levels already within normal range. It features six key nutrients that are involved in homocysteine metabolism: folate as calcium folinate and Quatrefolic® for increased bioactivity; trimethylglycine; vitamins B12, B6, and B2 and NAC. These six nutrients, provided in activated forms, support enhanced methylation and overall cardiovascular health. Homocysteine is produced by the demethylation of dietary methionine which comes from protein containing foods.

Adaptogen Research, Methylation Protect

Methylation Protect will Support:- 

  • Cardiovascular and Brain Health
  • Maintenance of Healthy Homocysteine Levels Already Within Normal Range
  • Supports Healthy Methylation of Estrogen, Dopamine, Epinephrine, Heavy Metals, and Environmental Toxins
  • Healthy aging
  • Strong immune system
  • Healthy detoxification
  •  Joint and cartilage structure

Copyright © Adaptogen Research. All Rights Reserved.

 Homocysteine Levels Tend To Rise With:-

  • Age -  Folate and B12 absorption decline in the elderly so they may require higher doses of these nutrients to lower their homocysteine levels effectively.  
  • Medications commonly taken by these individuals deplete folate, such as:-
  1. Ibuprofen 
  2. Other NSAIDs

Methylation Protect includes Quatrefolic® blend of active isomer, naturally-occuring folates. Research shows that supplementing 2-7 mg of folates daily helps to reverse plaque and prevent stroke.Research also shows that doses above 1000 mcg of B12 get absorbed effectively even without intrinsic factor.

Homocysteine Levels Need To be tested Twice Per Year When:-

  • Patients with a personal or family history of coronary heart disease, or other CHD risk factors, or who have the MTHFR (methyltetrahydrofolate reductase) faulty gene. ( Serum homocysteine can be ordered through any standard lab.)

 Testing For Deficiencies Of Folate, B6 and B12

  • bloodspot and/or urine collection.  (Serum or urinary methylmalonic acid (MMA) is the best marker of functional B12 status,) 

  1. ​The formiminoglutamate (FIGLU) marker is best for folate.
  2. Kynurenine and quinolinic acid elevations show a deficiency of B6.

Elevations of any of these markers on the CMP test may increase risk of homocysteinemia. Patients with hypothyroidism are at greater risk of hyperhomocysteinemia because hypothyroidism decreases hepatic levels of enzymes involved in the remethylation pathway of homocysteine. 

0-6.9 micromol/L
Optimum (low risk)
7 - 9.9 micromol/L
Mild risk
10.- 12.9 micromol/L
Moderate Risk
13 - 20 micromol/L
High risk
Over 20 micromol/L
Very high risk

Methylation Protect contains key nutrients that help maintain a healthy homocysteine pathway, allowing for the normal production of necessary and important end products. This formulation includes Folate, a proprietary blend of naturally occurring folates known to facilitate the efficient metabolism of homocysteine. These include the sulfur-containing amino acids taurine and cysteine, and the neurotransmitters norepinephrine and dopamine. The mineral zinc is also included in this formulation, because it is a necessary cofactor for the proper support of enzymes in the pathway. 

Made with non-GMO ingredients.
Manufactured in a GMP Registered Facility in the USA

Product Size: 120 vegetarian capsules
Servings Per Container: 60

Methylation Protect


  • The natural folate blend has been changed to L-5-MTHF and the dosage was lowered from 2.4 mg to 2 mg per serving due to the enhanced bioavailability of folate delivered exclusively in the L-5-MTHF form.
  • Trimethylglycine (TMG) has been increased from 500 mg to 900 mg per serving, as higher doses have been shown to be more effective in lowering homocysteine levels.

  • Serine, choline and zinc have been removed. Serine is a cofactor for converting folinic acid to L-5-MTHF, however since folate is now coming exclusively from L-5-MTHF, serine is no longer necessary. In addition, choline must convert to TMG to be effective and this is no longer necessary as TMG was significantly increased.

 It is recycled back into methionine through a pathway that involves vitamin B12 in the form of methylcobalamin (which remethylates it) and folate. Homocysteine is simply an intermediate in a very important biochemical pathway. Plasma homocysteine can also travel another route which involves the passing of sulfur groups (transsulfuration). This is vitamin B6-dependent and results in the production of cysteine which can convert into glutathione, the most important antioxidant in the body.

Homocysteine levels is an Independent Risk Factor for Hardening of:- 

  • The arteries 
  • Coronary heart disease
  • Stroke
  • Peripheral vascular disease
  • Other conditions associated with abnormal blood clotting.

Excess homocysteine in the circulation can damage the lining of arterial walls, making them narrow and inelastic.

Elevated Homocysteine Is Linked with A Number Of Other Serious Medical Conditions Including:-

  • Depression 
  • Osteoporosis 
  • Alzheimer’s Disease 
  • Multiple Sclerosis 
  • Rheumatoid Arthritis
  • Spontaneous Abortion 
  • Placental Abruption
  • Neural tube defects (spinabifida, Cleft palate, etc.) 
  • Renal failure
  • Type II diabetes

When homocysteine is elevated it reduces nitric oxide (NO) production, which can increase the risk of hypertension and erectile dysfunction. The synergistic nutrients included in Methylation Protect facilitate the efficient metabolism of homocysteine, and prevent toxic levels of homocysteine from accumulating. Methylation Protect allows the homocysteine pathway (which begins with methionine) to flow smoothly in any direction, producing its necessary and important end products, including the sulfur-containing amino acids taurine and cysteine and the neurotransmitters epinephrine, dopamine, and serotonin.

*These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. The information contained herein is for informational purposes only and does not establish a doctor-patient relationship. Please be sure to consult your physician before taking this or any other product. Consult your physician for any health problems.

Homocysteine Become Elevated Due To:-
Any roadblock in this pathway can cause homocysteine to elevate. When we intricately study the biochemistry of the homocysteine pathway we can see that it involves a series of conversions that require enzymes. Several nutrients, especially B vitamins, are needed for these conversions to occur. Stress can deplete B vitamins, as can many medications.

It is important to check B vitamin levels and also test the body's homocysteine levels. Performing both tests on women wishing to get pregnant could reduce the risk of neural tube defects and pregnancy complications. All patients with homocysteine levels above 7 micromol/L are in need of intervention with Methylation Protect being an ideal recommendation. Patients with a family history of early heart attacks or depression are also prime candidates for such intervention.