*These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. The information contained herein is for informational purposes only and does not establish a doctor-patient relationship. Please be sure to consult your physician before taking this or any other product. Consult your physician for any health problems.

Hist-D is a patented enzyme formula containing diamine oxidase (DAO)—the main enzyme responsible
for the degradation of ingested histamine. This enzyme has been clinically tested and found to break down
food-derived histamine in the digestive tract. DAO is not absorbed and does not have systemic activity.
Hist-D does not manage or address antibody-related or IgE-related food allergies.*

Histamine/DAO balance Endogenous and exogenous histamine must be broken down in order to maintain homeostasis and histamine balance. The enzyme diamine oxidase (DAO) degrades histamine by converting it from 2-(4-imidazolyl)- ethylamine to the inactive metabolite imidazole acetaldehyde. The active ingredient in Hist-D is porcine-derived diamine oxidase, and research suggests that DAO derived from porcine kidney appears to have identical action to DAO derived from porcine intestine. In humans and other mammals, DAO is found in high concentrations in the gastrointestinal mucosa. Animal studies suggest that circulating DAO may be a marker for mucosal integrity and maturity. Certain drugs may affect histamine balance in the body by promoting histamine release or inhibiting DAO.*

Histamine Tolerance Histamine tolerance may not be the same for everyone. Results of a double-blind, placebo-controlled crossover study suggest that tolerance to histamine can vary from individual to individual. Total body histamine load must be considered when evaluating histamine tolerance, and a balance between histamine and DAO appears to be crucial to maintaining skin, rhinoconjunctival, and gastrointestinal health.

Made with non-GMO ingredients.

Manufactured in a GMP Registered Facility in the USA

  • Product Size: 60 vegetarian capsules
  • Servings Per Container: 30


  • Supports Healthy Degradation of Food-Derived Histamine*
  • Enhances the Presence of Diamine Oxidase in the Digestive Tract*

Free of the following common allergens:- 

  • Wheat 
  • Gluten
  • Yeast
  • Soy
  • Animal 
  • Dairy Products
  • Fish
  • Shellfish
  • Peanuts
  • Tree Nuts
  • Egg
  • Ingredients Derived from Genetically Modified Organisms (GMOs)
  • Artificial Colors
  • Artificial Sweeteners
  • Artificial Preservatives.

Consult your healthcare professional prior to use. Individuals taking medication should discuss potential interactions with their healthcare professional. Avoid if allergic to pork or any other ingredient. Hist-D is NOT EFFECTIVE for symptoms of immune-related food allergies, such as peanuts, shellfish, etc., or for gluten intolerance due to sensitivity or celiac disease. Do not use if tamper seal is damaged. use if tamper seal is damaged.


Adaptogen Research, HisaCalm

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