It is recycled back into methionine through a pathway that involves vitamin B12 in the form of methylcobalamin (which remethylates it) and folate. Homocysteine is simply an intermediate in a very important biochemical pathway. Plasma homocysteine can also travel another route which involves the passing of sulfur groups (transsulfuration). This is vitamin B6-dependent and results in the production of cysteine which can convert into glutathione, the most important antioxidant in the body.


  • The natural folate blend has been changed to L-5-MTHF and the dosage was lowered from 2.4 mg to 2 mg per serving due to the enhanced bioavailability of folate delivered exclusively in the L-5-MTHF form.
  • Trimethylglycine (TMG) has been increased from 500 mg to 900 mg per serving, as higher doses have been shown to be more effective in lowering homocysteine levels.

  • Serine, choline and zinc have been removed. Serine is a cofactor for converting folinic acid to L-5-MTHF, however since folate is now coming exclusively from L-5-MTHF, serine is no longer necessary. In addition, choline must convert to TMG to be effective and this is no longer necessary as TMG was significantly increased.

Methylation Protect will Support:- 

  • Cardiovascular and Brain Health
  • Maintenance of Healthy Homocysteine Levels Already Within Normal Range
  • Supports Healthy Methylation of Estrogen, Dopamine, Epinephrine, Heavy Metals, and Environmental Toxins
  • Healthy aging
  • Strong immune system
  • Healthy detoxification
  •  Joint and cartilage structure

Methylation Protect is a comprehensive formula designed to support optimal methylation and help maintain healthy homocysteine levels already within normal range. It features six key nutrients that are involved in homocysteine metabolism: folate as calcium folinate and Quatrefolic® for increased bioactivity; trimethylglycine; vitamins B12, B6, and B2 and NAC. These six nutrients, provided in activated forms, support enhanced methylation and overall cardiovascular health. Homocysteine is produced by the demethylation of dietary methionine which comes from protein containing foods.

*These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. The information contained herein is for informational purposes only and does not establish a doctor-patient relationship. Please be sure to consult your physician before taking this or any other product. Consult your physician for any health problems.

Made with non-GMO ingredients.
Manufactured in a GMP Registered Facility in the USA

Product Size: 120 vegetarian capsules
Servings Per Container: 60

Notice:  Color, Size or Shape May Appear Different Between Lots

Methylation Protect

Methylation Protect contains key nutrients that help maintain a healthy homocysteine pathway, allowing for the normal production of necessary and important end products. This formulation includes Folate, a proprietary blend of naturally occurring folates known to facilitate the efficient metabolism of homocysteine. These include the sulfur-containing amino acids taurine and cysteine, and the neurotransmitters norepinephrine and dopamine. The mineral zinc is also included in this formulation, because it is a necessary cofactor for the proper support of enzymes in the pathway. 

Adaptogen Research, Methylation Protect

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