Physiologically active pregnenolone, derived from natural diosgenin sterols, is micronized to a very small particle size to facilitate absorption.

Made with non-GMO ingredients.
Manufactured in a GMP Registered Facility in the USA

  • Product Size: 100 vegetarian capsules
  • Servings Per Container: 100

Pregnenolone 25 mg

Free of the following common allergens:- 

  • Dairy 
  • Gluten 
  • Soybeans
  • Eggs fish 
  • Shellfish 
  • Tree nuts
  • Peanuts
  • Wheat
  • Corn 

Contains no Artificial Colors, Flavors, or Preservatives.

Caution
Not for use by individuals under the age of 18 years. Do not use if pregnant, may become pregnant, breastfeeding, or have a history of seizures. This product is not intended for long-term daily use. If you have a medical condition (including a family history of breast, uterine, ovarian, prostate or heart disease) have low HDL cholesterol, or are taking prescription drugs, consult your physician before using this product. KEEP OUT OF REACH OF CHILDREN.

*These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. The information contained herein is for informational purposes only and does not establish a doctor-patient relationship. Please be sure to consult your physician before taking this or any other product. Consult your physician for any health problems.

Twice Daily Formula - 2 A Day Multi - Adaptogen Research
  • Pregnenolone plays a key role in hormonal balance as a key precursor to cortisol, dehydroepiandrosterone (DHEA) and progesterone, and helps to maintain balance in the body’s stress response system. In addition, pregnenolone has been shown to support a balanced mood and promote cognitive health by modulating the transmission of messages between neurons, influencing learning and memory processes. Since there is strong evidence that pregnenolone levels diminish with advancing age, restoring these levels may also help support overall brain function and sense of well-being.


  • Pregnenolone is a prohormone that is synthesized in the brain and adrenals, but also in the liver, skin, brain, testicles, ovaries, and retina. As a biochemical precursor to DHEA and progesterone, pregnenolone helps maintain a normal balance between these hormones in the body and as a result, helps to modulate the cortisol-driven stress response system, support nerve cell growth and modulate mood. In addition to its function as a prohormone, pregnenolone is a neurosteroid that is found in high concentrations in the brain where it protects neurons, enhances myelination and supports cognitive health and memory. Pregnenolone supplementation is particularly important for those who have been found to have deficient hormone levels through testing, as well as those who need cortisol-to-DHEA ratio support.

 

  • Pregnenolone levels naturally peak during youth and begin a long, slow decline with age. Since pregnenolone is the parent compound of other vital neurosteroids such as DHEA1, declining levels of pregnenolone could leave brain cells increasingly vulnerable to overstimulation by neurotransmitters like glutamate,1,2 thereby affecting mood and cognition. 

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Research has shown pregnenolone to be beneficial for mood support and balance. 

Specifically, pregnenolone is reported to have a positive effect on:- 

  • Neuronal excitability and synaptic plasticity
  • Has many other functions associated with mood regulation
  • Neuroprotection from free radicals
  • Balancing the stress response
  • Improving cognitive performance.


In a study of 15 adults with mood imbalance, blood levels of pregnenolone were lower among those with low mood, compared to controls.   Among 70 adults with mood imbalance who received either pregnenolone or placebo, the pregnenolone group trended toward greater improvement in mood, relative to the placebo group on rating scales.   Additionally, an eight-week, double-blind, randomized, placebo-controlled study that compared 30 mg/day or 200 mg/day pregnenolone, 400 mg/day of DHEA, and placebo found those given the 30 mg pregnenolone had significant reductions in positive symptom scores along with an improvement in attention and working memory performance. Further improvements were not found among groups given higher amounts of pregnenolone.