Others who may benefit from L-5-MTHF:


  • Pregnant women and women wishing to become pregnant who have familial history of depression, high homocysteine levels, or genetic defect in MTHFR.

Note: All pregnant women should take Prenatal Supreme as their comprehensive multivitamin; can combine with L-5-MTHF if higher levels of folate are needed.

  • Women with abnormal pap smears (precancerous)
  • Those with very high homocysteine levels not responding quickly to Methylation Protect (consider using them together)
  • Dialysis patients
  • Organic acid testing that reveals elevated FIGLU (marker used to identify folate deficiency)
  • Patients with family history of dementia/vascular dementia
  • Patients with depression
  • Long-term alcoholism


Long-term use of oral contraceptives, and persistent use of medications to lower folate levels, including high doses of NSAIDs such as aspirin or ibuprofen; anticonvulsants (phenytoin, phenobarbital, and primidone); trimethoprim (antibiotic), pyrimethamine (antimalarial), triamterene (blood pressure med.) and sulfasalazine (treatment for ulcerative colitis).

Do not take 5-MTHF simultaneously with the cholesterol-lowering agents cholestyramine or colestipol because they may decrease the absorption of folate.

Individuals who have tested homozygous with either the A1298C or C677T MTHFR mutation, or those with elevated homocysteine levels, should be using L-5-MTHF as the preferred form of folate supplementation. This will be more effective for them than other forms of folic acid or folates.   L-5-MTHF is a safe and effective way to increase the body’s folate levels. It is especially helpful for patients with demonstrated increased need for folate such as those with either the A1298C or C677T MTHFR mutation.


This product provides 1000 mcg per capsule of folate in the bioidentical, bioactive form, 5-Methyltetrahydrofolate. L-5-MTHF (the "L" signifying that it is the all-natural [6S] isomer) is the active circulating form of folate found in the body and one of the several forms found in food. In nature it is found only as this [6S] isomer, which is why Adaptogen Research provides 5-MTHF as this natural isomer rather than the mixed (or racemic) form. 

Made with non-GMO ingredients.
Manufactured in a GMP Registered Facility in the USA

  • Product Size: 120 vegetarian capsules
  • Servings Per Container: 120

Better adaptability through pure ingredients and nutritional science

L-5-MTHF 

Copyright © Adaptogen Research. All Rights Reserved.

*These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. The information contained herein is for informational purposes only and does not establish a doctor-patient relationship. Please be sure to consult your physician before taking this or any other product. Consult your physician for any health problems.

Adaptogen Research, L-5- MTHF, Natural S-Isomer

L-5-MTHF should be used when high doses of folate are needed

High Dose, 1000 mcg Methylated Folate, as the all Natural 6S Isomer


Our L-5-MTHF uses the patented folate derivative Quatrefolic®.  This innovative form of folate has demonstrated high bioavailability and solubility as well as long lasting stability. Quatrefolic® L-5-MTHF helps to increase blood folate levels much better than folic acid. 

Benefits of L-5-MTHF

  • Supports healthy fetal development
  • Helps maintain proper homocysteine levels
  • Supports normal mental function
  • Aids in the relief of occasional nervous tension
  • Helps maintain healthy cardiovascular function