Stabilized R-Lipoic Acid Plus Benefits:- 

  • A naturally occurring vitamin-like nutrient that has been intensely investigated as a beneficial agent for a variety of bodily functions involving:- 
  1. The nervous 
  2. Cardiovascular
  3. Immune
  4. Detoxification system.
  • Produced in small amounts in the liver and other body tissues, where it is needed by enzymes to catalyze numerous essential chemical reactions in the body.
  • Essential inside the mitochondria of cells, where it is needed to metabolize glucose and direct calories into energy production
  • Considered to be a multimodal supplement because, aside from its enzymatic role in energy production, it acts by multiple mechanisms and displays diverse health-enhancing and antioxidant properties

Boosts Energy Production/Mitochondrial Cofactor
RLA is the majority of lipoic acid found in nature and therefore likely to fit better as a cofactor for mitochondrial enzymes pyruvate and alpha-ketoglutarate dehydrogenase.5 SLA cannot bind well to these enzymes and actually inhibits them.  Thus the S-form can oppose the action of the R-form. In the aging rat heart, RLA stimulated ATP production, whereas SLA inhibited it.

RLA supplementation improves metabolism, measured as oxygen consumption in liver cells, and improves ambulatory activity in supplemented animals, bringing old treated animals to the level of young animals.  Pre-treatment of brain cells with RLA leads to the restoration of the mitochondrial activity lost due to glutathione depletion

Adaptogen Research Stabilized RLipoic Acid Plus  is sourced from the only stable and highly bioavailable form of R-Lipoic Acid available on the market Compared to SLA, RLA causes 50% higher peak plasma levels of lipoic acid and 60-85% higher total absorption.   Feeding lipoic acid to animals at risk of cataract caused a 2-7 fold higher uptake of RLA versus SLA in the lens content of lipoic acid, and reduced the development of experimentally produced cataract by 50%.

R-Lipoic Acid
R-Lipoic Acid (the R (+) enantiomer) is the form of lipoic acid that occurs naturally in plants, animals and the human body and is responsible for the specific beneficial effects of Alpha-Lipoic acid. R-lipoic acid (RLA) is the only form that functions as a co-factor for mitochondrial enzymes involved in energy production.

Made with non-GMO ingredients.
Manufactured in a GMP Registered Facility in the USA

  • Product Size: 60 vegetarian capsules
  • Servings Per Container: 60

*These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. The information contained herein is for informational purposes only and does not establish a doctor-patient relationship. Please be sure to consult your physician before taking this or any other product. Consult your physician for any health problems.

Adaptogen Research, Stabilized R-Lipoic Acid Plus

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Acid Plus

Stabilized R-Lipoic 

Lipoic Acid Chemical Forms: the R and S Isomers 
When Alpha-Lipoic Acid is synthesized in a laboratory, a 50/50 racemic mixture of the R and S enantiomers results in what we call R/S Lipoic Acid, which is the most popular form of commercially available Lipoic Acid (also named RAS Lipoic Acid or All Racemic Lipoic Acid). Our patients know it as simply Alpha Lipoic Acid. 
New technological advancements have allowed for the stabilization and isolation of the RLA (R-Lipoic Acid isomer), which is believed to account for all the benefits seen from studies with R/S Lipoic Acid. Supplementing with pure RLA, thus eliminating the presence of SLA (S-Lipoic Acid isomer), creates new opportunities for intensive nutritional support because SLA is believed to interfere with the effectiveness of RLA. 
How is Stabilized R-Lipoic Acid Different From Other R-Lipoic Products on the Market? 
R-Lipoic Acid  is a highly unstable compound that easily polymerizes into a sticky rubber or glue-like substance if it is not prepared, stored and processed correctly. This will adversely affect bioavailability. Stable RLA is a non-hygroscopic, non-polymeric potassium salt form of RLA. The capsules are heat stable, characterized by fast dissolution rates, high solubility and absorption. They are also free of residual solvents and moisture. There are wide variations in the R/S ratios and total polymer contents of raw material and finished products now on the market. Few supplement companies have experience with RLA and are unaware of the myriad of problems associated with its encapsulation and stability.

Stabilized R-Lipoic Acid Plus, which many may simply know as lipoic acid, provides a stabilized and isolated RLA (R-lipoic acid isomer) thanks to technological advancements. Since SLA (S-lipoic acid isomer) can interfere with RLA’s efficacy, supplementing with pure RLA provides a significant advantage for intensive lipoic acid supplementation. Once separated from SLA, RLA is extremely unstable. Binding RLA to potassium, as found in this unique product, solves this problem. Unlike other R-Lipoic products, Stabilized R-Lipoic Acid is a non-hydroscopic, non-polymeric potassium salt form of RLA.

Enhanced Glucose Metabolism

  • RLA significantly increases insulin sensitivity, glucose transport, metabolic rate and reduces the gain in body fat associated with aging.  R-lipoic acid has insulin-mimetic effects in glucose uptake in insulin resistant cells and may have therapeutic implications in restoring glucose availability in tissues such as the skeletal muscle.  The RLA was found to enhance insulin-stimulated glucose transport and non-oxidative/oxidative glucose metabolism by as much as 64%, while SLA had no effect. Also, RLA decreased insulin by 17% while SLA increased it by 15%.   Through its positive effects on cellular energy metabolism, RLA attenuates metabolic dysfunction associated with advanced glycation end products (AGEs). AGEs accumulate on long-lived proteins, including beta-amyloid plaques in Alzheimer's disease and contribute to neuronal dysfunction and cell death.

Antioxidant Properties

  • RLA increases cellular and mitochondrial antioxidant activity, and was able to eradicate the age-related changes in animal models. This effectively attenuates the reported age-related increase in oxidative stress.  RLA significantly increases or recycles other antioxidants including coenzyme Q10, vitamin C, vitamin E and glutathione.   RLA protects lipids against peroxidation and reverses stress damage in the heart.   Anti-inflammatory Effect RLA, a membrane permeable antioxidant, prevents the up regulation of the AGE-induced gene expression responsible for regulating nitric oxide (NO) production. NO oxidizes nitrates and proteins which are markers of a chronic neuro inflammatory condition. This mechanism is relevant for Alzheimer's disease and for many chronic inflammatory conditions.  RLA reduces inflammation, and is more potent by a factor of 10 over R/S-LA. 

Metal Chelator

  • RLA was more effective than the SLA in a battery of metal chelation tests. One hypothesis of the cause of diabetic complications involves overloading by transition metals, which implicates the RLA as more effective in treating diabetic neuropathy.


  • RLA improves memory, reverses cognitive dysfunction, and protects the brain from neuro-degeneration associated with aging. This may be due to its effect on increased ATP production, chelating, antioxidant and anti-glycating capacity